Top Ten Ways To Move Cures Forward, Every Now Forward

1.   Like CureSearch on Facebook and tell your friends to do the same!

2.   Donate the cost of a night out at the movies and help CureSearch fund innovative research to make treatment possible and a cure probably for kids fighting cancer today and int he future.

3.   Doing some last minute shopping? Look no further than Red Envelope! Visit their website today, $10 of every purchase will be donated to CureSearch!

4.   Donate $36 for the 36 children diagnosed with cancer every day.

5.   Tell you friends that the money raised by CureSearch helps make treatment possible and a cure probable for kids fighting cancer today and int he future.

6.   In honor of the 36 children diagnosed with cancer every day, Pro Flowers will donate $10 of every order you make! Be sure to visit their site and help support children’s cancer research.

7.   Tell your friends that children’s cancer affects all ethnic, gender, and socio-economic groups. CureSearch is dedicated to funding research to change the odds for those children most at risk.

8.   Join one of CureSearch’s events such as the CureSearch Walk or Ultimate Hike.

9.   Follow CureSearch on Twitter.

10.   Donate to CureSearch because every 40 minutes, a family hears the words “your child has cancer.” A donation makes it possible for these families to receive the best treatment possible at a hospital near them.

Order your Bravelet today! For every Bravelet purchased, $10 will be donated to CureSearch!

bravelets

Bravelets is a non-profit organization that is dedicated to giving back to organizations making a difference in the community.

During December, Bravelets will donate $10 of every purchase of a CureSearch for Children’s Cancer Bravelet to CureSearch!

Don’t wait, buy your Bravelet today and help CureSearch continue to accelerate the cure for children at greatest risk of losing their battle with cancer, support clinical trials for children at local hospitals, and provide resources and education for families.

CureSearch Awards $1.2 Million in Grants

CureSearch for Children’s Cancer has awarded $1.2 million in clinical trials support to 77 hospitals who applied for Clinical Trials Advancement Awards. All hopsitals who applied for grants received funding for enrolling infants, children, adolescents, and young adults in Phase I, Phase II, and Phase III therapeutic clinical trials.

Clinical Trials Advancement Awards range from $5,000 to $40,000 and are based on a set criteria detailed in the grant application, but include balancing the number of enrollments with a hospital’s involvement in the CureSearch Walk.

Hospitals can begin applying for 2014 funding in May, 2014 and award notices will be distributed in December, 2014.

New Young Investigator Program Podcast Available!

Hear how Eric Raabe is studying what causes rare DIPG brain tumors. 

Diffuse Intrinsic Pontine Glioma (DIPG) is one of the most devastating childhood cancers, with mean survival times of a little more than a year. DIPG is a type of central nervous system cancer that is located in the pons section of the brain. The pons controls breathing and swallowing, as well as movement in the face and head, and arms and legs. DIPG tumors cannot be removed because they lack an identifiable border, and they take over a location in the brain necessary for survival.

DIPG is a very rare childhood cancer and primarily affects children between 3-10 years old. The cancer is treated aggressively with radiation but in the last 30 years, no other treatments have been shown to extend a child’s life beyond 1 to 2 years. Diagnosed by unique characteristics that appear on MRI, until recently there was very little DIPG tissue available for researchers to study. Thanks to new autopsy processes, in recent years researchers have begun to study DIPG tissue and in doing so have found that a specific gene mutation is present in about 70% of DIPG tumors.

Read more about Eric Raabe’s research.

Meet the Children: Nick Wolf

In May 2011, Nick Wolf was experiencing a persistent headache and nausea. His mother, Christina, took him to the doctor who informed them that she suspected Nick had a brain tumor, but that they should monitor his symptoms to see if they persisted. The headaches and nausea continued and one day Nick started uncontrollably clenching and unclenching his hand. His mom took him back to the doctor, and an MRIwas ordered.

The family tried to schedule an MRI, but were told that they would have to wait several days for the procedure. When Nick’s pain became unbearable, they rushed him to the hospital where their worst fears were confirmed. Nick had a 5cm Primitive Neuroectodermal tumor (PNET) on the right side of his brain that would require surgeryradiation, and chemotherapy. The family prepared for surgery and the months of treatment that would follow. Luckily, their surgeon was able to remove the tumor completely, significantly increasing Nick’s chance for beating cancer.

After the surgery Nick was discharged from the hospital to recover before starting radiation and chemotherapy. When Nick went home, he was too weak to walk unassisted, but was determined to get stronger before treatment started. He began playing Wii Fit to help regain his strength and within a few weeks, he was walking on his own.

Read more…

Developing CD47 Antibody Therapy for Children’s Cancer

A research team at Stanford University led by Drs. Kathleen Sakamoto and Irv Weissman has received a $1.37 million grant from CureSearch titled “Development of CD47 Monoclonal Antibody Therapy for Pediatric Tumors.”

In a healthy person, when the body makes abnormal cells or cells become old, the body’s scavenger cells, called macrophages, eliminate them in a process defined as programmed cell removal. When a person has cancer, the abnormal cells are not eliminated by the macrophages. Researchers under the leadership of Dr. Irv Weissman discovered that pediatric brain tumor, leukemia, bone tumor and neuroblastoma cells overproduce a cell surface protein known as CD47. The overproduction of CD47 on cancer cells tells macrophages “don’t eat me,” allowing the disease to progress.

Read more…

Meet the Children: Melissa Mugno

Melissa Mugno 1

In February of 2009, Melissa broke her leg and was rushed to the ER. Her doctor ordered an x-ray to determine the best way to fix her broken leg, and noticed an abnormality, causing them to order an MRI to get a better picture. Later that day, Melissa and her parents received news that no one should ever hear; their 13-year-old daughter had osteosarcoma. Her doctors found cancer in her right hip, femur, and knee. Melissa underwent several rounds ofchemotherapy and eventually had to have her bones fused due to complications from treatment. When she went into remission, her family was ecstatic.

The celebration was short lived because in May of 2010, doctors found cancer in Melissa’s lungs. She had chemotherapy and surgery on her lungs later that year, and went into remission again, this time for a year.

In 2011, her family received the news that Melissa had relapsed again in her lungs and would have to undergo chemotherapy and another surgery. The treatment was successful, but only for a short time, because Melissa relapsed for a third time in 2012. The family began looking for alternative treatments and ended up in Orlando for a clinical trial. The trial went well, and Melissa was declared in remission.

Read more…