Topics will focus on emerging themes in laboratory science
On October 17-18, CureSearch will host its second annual research symposium in Washington DC. This year’s Symposium, entitled “Translational Oncology: Emerging Targets in Childhood Cancer” will focus on emerging themes in laboratory science with potential for early implementation. Featured speakers include Malcolm Smith, James Bradner, and John Maris.
The Symposium offers special networking opportunities for young investigators seeking careers in clinical or translational oncology. For more information about the event, including registration and hotel information, please visit www.curesearch.org/Symposium. We hope to see you there!
In seventh grade, Cora found a lump in her breast. She and her mother Martha went to the doctor to see what was causing the lump. Cora’s doctors performed an ultrasound, but the results were inconclusive. After another ultrasound her team of doctors determined that she had a tumor. They weren’t sure what type of cancer Cora had, but they knew that they had to remove it.
Cora had surgery at Children’s Hospitals and Clinics of Minnesota, where doctors discovered that she had a rare form a skin cancer called Dermafibrosarcoma Puterberan. Another surgery was needed to ensure that clear margins were obtained. Since then Cora continues to be monitored by her oncologist and surgeon.
While they were at the hospital, Cora saw a poster for the CureSearch Walk and told her mom that she wanted to get involved. They formed a team – Cora’s Pink Posse – and started fundraising right away. Cora has taken the lead on organizing events and motivating her teammates to continue fundraising. Helping other children with cancer has become her passion. “We love seeing people come together to support survivors and those who have lost their battles,” says Martha. “Seeing people come together is really moving. The CureSearch Walk has become a great community.”
We are very pleased to introduce the inaugural National CureSearch Walk Committee (NCWC). The NCWC is a group of volunteers from across the country who have been involved with the CureSearch Walk for 2+ years and have a desire to help shape the program by lending their collective ideas, opinions, and expertise to the national platform. NCWC were nominated and chosen for their individual contributions to their local Walk and their ideas to help the national CSW program grow.
Below you will find brief bios about each member, their family and their involvement with CureSearch for Children’s Cancer.
Researchers and physicians know that children who undergo cancer treatment are at risk for decreased bone mineral density because many cancer treatments negatively affect bone health. It is particularly important that children and adolescents develop strong bone density because bone strength decreases in adulthood. Despite this knowledge, little is known about the rate at which fractures actually occur in survivors of childhood cancer and if they can be prevented.
Lynda Vrooman, MD, MMSc of Dana-Farber Cancer Institute is a CureSearch Young Investigator interested in better defining the risks and long-term consequences of fracture in survivors of childhood cancer, and in intervening to minimize long-term complications. During her first year of research, Dr. Vrooman completed enrollment of 193 patients in a study of reported bone fracture. Her findings demonstrate that approximately 25% of cancer survivors experienced at least one fracture after cancer treatment. Of those with fracture, 35% experienced more than one fracture after treatment. In addition, survivors treated with corticosteroids, commonly used in the treatment of many types of children’s cancer, experienced significantly higher rates of fracture after cancer treatment. These results highlight the importance of minimizing the bony complications associated with corticosteroids and suggest that a treatment-associated fracture risk may extend beyond cancer therapy completion.
In the next year of her work, Dr. Vrooman will conduct detailed bone density testing in childhood cancer survivors with a history of fracture. Dr. Vrooman anticipates that this work will inform future interventional studies aimed at decreasing skeletal toxicity in survivors of childhood cancer.
21-month-old Margo Miller hadn’t been herself for weeks. She had a fever on and off, was cranky at daycare, and wasn’t eating well. Her mother, Gina, took her to their pediatrician to see what could be causing her behavior.
Her pediatrician couldn’t find anything that could be causing her pain, but suggested that Gina bring Margo back on Monday so that they could run some additional tests. They went home and tried to enjoy a normal weekend.
On Monday, Gina and Margo headed back to the pediatrician, where her they noticed red dots on her legs. Gina was told that Margo had to have a blood test done immediately. Once the blood work came back, their pediatrician told them news that they never hoped to hear, Margo had acute lymphocytic leukemia (ALL).
CureSearch for Children’s Cancer is now accepting applications for six (6) Young Investigator Grants. These “Young Investigator Pathway to Independence Grants” are funded at $225,000 each over three years and are available in the areas of neuroblastoma, palliative care, rhabdomyosarcoma, and three “open” areas. “Open” applications may be in disease or discipline areas of pediatric oncology and will be based on the merits of the research proposed, the productivity of the applicant, mentorship, and environment.
Awards will be announced in October, 2014 and funding will begin in January, 2015.
For those interested in applying, RFAs are posted onproposalCENTRAL.altum.com.
(Wall Street Journal Online) – April 28, 2014: New treatments and earlier detection have led to steady gains in cancer survival for children and adults. But survival rates for teens and young adults with some types of cancer have barely budged in 30 years.
A push is on for better care and better outcomes for patients in what the National Cancer Institute calls a “no man’s land” between pediatric and adult oncology. At present, adolescents and young adults may be treated in adult units or in children’s wards – which both are places they are likely to feel isolated and distressed.
More hospitals are adding dedicated teen and young adult cancer units based on a model developed by the Teenage Cancer Trust in the U.K. It teams medical oncologists, pediatric specialists, therapists and social workers to offer an integrative approach to medical treatment, emotional issues, fertility counseling and clinical trials.