Late effects linked to poor quality of life in long-term childhood cancer survivors

Improved treatments and technologies are leading to more children than ever who survive cancer. Unfortunately, about 70% of these children experience late effects from their disease and treatment
30 years after their cancer diagnosis. These effects significantly impact their quality of life.

“The prevalence of these symptoms accounts for a huge variance in physical, mental, and social domains of quality of life among survivors,” said lead author I-Chan Huang, PhD, of the University of Florida Health College of Medicine in Gainesville. “If we think symptoms are the key to patients’ quality of life, then if we can better manage their symptoms, we can improve their daily functional status and quality of life.”

The study, which was conducted with St. Jude Children’s Research Hospital in Memphis, Tennessee, and published in the Journal of Clinical Oncology (2013; doi:10.1200/JCO.2012.47.8867), analyzed data from 1,667 childhood cancer survivors who participated in a St. Jude study looking at the long-term effects of cancer survival. The researchers used a patient-reported survey to measure quality of life. A specific symptom scale was designed to assess toxicities related to cancer treatment as outlined in the Children’s Oncology Group guidelines.

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