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Lighting the Way for Children's Cancer Cures. Impact Report - December 2015

CURESEARCH MISSION

Our mission is to end children's cancer by driving targeted and innovative research with measurable results in an accelerated time frame.


RESEARCH VISION

Improve children's cancer treatment and cures to deliver the potential for childhood cancer patients to lead long, healthy lives.



MESSAGE FROM THE CEO


Next year will mark the 45th anniversary of President Nixon's declaration of war on cancer, and the intervening years have seen remarkable changes in how we understand, diagnose, and treat cancer. Yet for all of the progress, children still die of cancer at unacceptable rates, there are few anti-cancer treatments specifically designed for children, and there are numerous institutional impediments to quickly finding and delivering safe and effective treatments to pediatric patients.


CureSearch for Children's Cancer and our partners - representing the spectrum of researchers, families, pharmaceutical and biotechnology companies, regulatory agencies, and advocates - agree it's time for a fundamental change in the way we approach the development and delivery of cancer interventions for children. That's why over the next two years we are launching our Catapult Initiative, a program that will offer assistance to treatment developers to facilitate and expedite the advancement of promising treatments through the labyrinth of research and regulatory processes that often impede or prevent the testing and delivery of new interventions.


We are excited to launch this initiative with our first Catapult Summit this February in San Francisco and we look forward to updating you on our progress in the year ahead.


Laura Thrall
CEO
CureSearch for Children's Cancer

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TO CHILDREN'S CANCER RESEARCH

CURES WITH INTEGRITY


The CureSearch core values guide us as we push forward in finding cures and less-toxic treatment for children with cancer.


HONESTY & INTEGRITY
TRANSPARENCY & ACCOUNTABILITY
CREATIVITY & COLLABORATION



THE CURESEARCH DIFFERENCE


We focus only on children's cancer.
We're not here just to fund research, we're here to drive patient impact.
Our Scientific Advisory Council and Scientific Review Board brain trust is unmatched.
We invest in large-scale grants over a three-year timeframe, which allows our researchers to focus on their work, not fundraising.
We hold ourselves - and our grant recipients - accountable through a novel measurement framework and frequent reporting to our constituents.
We build strong, long-term partnerships with our funded researchers so that successful work is supported beyond the scope of their original CureSearch grant.
We are bridging the 'valley of death' by creating unique partnerships with biotech and pharma to ensure that promising research makes it out of the lab and into the clinic.

THE CURESEARCH PROMISE


Because soon is not soon enough, CureSearch continues to accelerate the search for new cures. CureSearch bridges the gap between basic research discoveries and getting new cures to kids by:



INVESTING IN HIGH-IMPACT RESEARCH

23
Investigators
14
New Therapies
15,780
Children Affected
Each Year

(0-19 Years of Age)

BRINGING SUBJECT MATTER EXPERTS TOGETHER


CureSearch, in partnership with HeathSpottr, is hosting The Catapult - a summit event for our funded researchers, board members and key advisors to engage with experts from industry, academia, advocacy, policy formation and regulation. This day-and-a-half summit will explore and accelerate strategic opportunities to advance the delivery of new pediatric cancer treatments to children.

Healthspottr CureSearch Catapult 2016

FOSTERING TRANSFORMATIVE PARTNERSHIPS


Knowing that we cannot win the fight to end children's cancer alone, CureSearch fosters relationships with other cancer foundations including Rising Tide Foundation for Clinical Cancer Research and Gateway for Cancer Research.

Gateway for Cancer Research Rising Tide Foundation For Clinical Cancer Research

We are also building partnerships with the pharmaceutical industry, and facilitating relationships between academic researchers and the industry partners that can translate new treatments to patient-ready drugs.



CHALLENGE ACCEPTED



Sheri Sobrato BrissonSheri Sobrato Brisson, trustee of the Sobrato Family Foundation and a brain tumor survivor, has generously supported Dr. Gilbertson's work with a $250,000 contribution to CureSearch. In an effort to ensure this award is quickly and fully funded, Ms. Sobrato Brisson has pledged an additional $100,000 if CureSearch can secure $100,000 in matching funds specific to this project before December 31, 2015. If we are able to secure the additional matching funds by year-end, CureSearch will have fully funded the Gilbertson research project.

SUPPORT THE CHALLENGE.
DONATE TODAY



ACCELERATION INITIATIVE


This $10M trailblazing initiative is our commitment to surface the most promising children's cancer research, drive it to clinical practice, and quickly find better treatments and cures.

Drug Discovery & Development Pipeline

ACCELERATION INITIATIVE 2

$1.69M over three years
(2015-2018)

Rising Tide Foundation For Clinical Cancer Research CureSearch Promise Logo

Two awardees selected in partnership with
Rising Tide Foundation for Clinical Cancer Research.


Richard Gilbertson, MD, PhD
Richard Gilbertson, MD, PhD

University of Cambridge
$835K


Targeted Therapies for High-risk
Brain Tumors


ANTICIPATED OUTCOMES

30 drugs to be tested
3 High-Risk brain tumor subtypes
1 Novel pre-clinical trial design
20,000 Genes to be analyzed

Maria-Grazia Roncarolo, MD
Maria-Grazia Roncarolo, MD

Stanford University
$855K


Cell-based Therapy for AML


ANTICIPATED OUTCOMES

1 Novel cell therapy delivered
1 Clinical Trial planned within three years

LEARN MORE ABOUT THE
ACCELERATION INITIATIVE 2

ACCELERATION INITIATIVE 1

$5M over three years
(2013-2016)


Mary Beckerle, PhD  A Novel Epigenetic Strategy to Treat Ewing Sarcoma

Huntsman Cancer Institute
University of Utah
Epigenetics


$1.73M


1
Lead compound in late preclinical testing
 
2
Novel tumor model designs
 
35
Patient samples
 
1
Novel biomarker study developed


"CureSearch funding has facilitated our current studies focused on performing essential toxicity, stability and efficacy studies in our preclinical models in advance of human clinical trials."

- Mary Beckerle, PhD



Progress Report


William Weiss, PhD  Overcoming Resistance in Medulloblastoma

The Regents of the
University of California, CA
Epigenetics


$1.88M


3
Drugs for high risk medulloblastoma in preclinical testing
 
2
Novel tumor model designs
 
28
Patient biopsies studied
 
1
Novel gene signature linked to high risk medulloblastoma


"CureSearch support has enabled our team to identify previously unrealized epigenetic changes in high-risk MB that can be targeted by existing or emerging drugs."

- William Weiss, PhD



Progress Report


Kathleen Sakamoto, MD, PhD

Stanford University
Immunotherapy*


$1.37M


1
Novel treatment for multiple pediatric cancers
 
1
Adult trial nearing completion
 
3
Number of Adolescent Young Adult (AYA) patients referred


"We are thankful for CureSearch's support. The adult trial is progressing well and we are currently enrolling adolescent young adult (AYA) patients. We anticipate this will enable us to launch a pediatric trial in 2016."

- Kathleen Sakamoto, MD, PhD


*Studies deferred.


Progress Report



YOUNG INVESTIGATORS


The CureSearch Young Investigator program is designed to attract early stage investigators and feed the pipeline for future Acceleration Initiative investigators. YI Grants fund transformational science designed to deliver the next generation of cancer treatment.






YOUNG INVESTIGATOR 2

$1.35M over three years
(2015-2018)


Encouraged by the promise and success of our first twelve Young Investigators, CureSearch awarded six new grants in 2015. The new grant term is three years and the award has more than doubled. After one year, each of the grantees has made substantial progress toward finding new treatments.



SIX YOUNG INVESTIGATOR 2 GRANTEES


Ranjit Bindra, MD, PhD
Yale University
Rhabdomyosarcoma


Kara Davis, DO
Stanford University
BCP-ALL


Anthony Graves, MD, PhD
University of Pittsburgh
Neuroblastoma


Andrew Lee Hong, MD
Dana-Farber Cancer Institute
Wilms Tumor


Brigit Knoechel, MD, PhD
Dana-Farber Cancer Institute
T-cell ALL


Abby Rosenberg, MD, MS
Seattle Children's Hospital
Palliative Care for AYA

 

Cumulative Impacts


1 clinical trial, 4 drugs in pre-clinical test, 7 new cell lines, 226 drug targets, 100K compounds, 4 high-throughput drug screening tests, 3 genomic screens analyzing 20,000 genes




YOUNG INVESTIGATOR 1

$1.2M over two years
(2012-2014)


Twelve researchers focused on high-risk, poor outcome cancers:


  • Acute myeloid leukemia (AML)
  • Adolescent and young adult tumors
  • Acute lymphoblastic leukemia (ALL)
  • Neuroblastoma
  • Hodgkin lymphoma
  • Rhabdomyosarcoma
  • Late effects / survivorship
  • Bone, liver, brain and renal tumors
 

Cumulative Impacts

240 patients enrolled in two clinical studies, 5 drug therapies in preclinical testing, 22 tumor models used, 360 drug targets identified, 14,140 genes investigated

CURESEARCH COMMUNITY
IMPACT AWARDS


CureSearch has supported clinical trials in hospitals across the country for many years. In October 2015, we awarded two types of awards for local institutions.


$240,000


Community Impact Awards
(CCIA) for Caregivers


14 Children's hospitals across the U.S. awarded for programs to support patients and caregivers in psychosocial programs, professional training or educational resources.

Gateway For Cancer Research$260,000


Gateway For Cancer ResearchCommunity Impact Awards for Clinical Trials (CCIA-CT)

In Partnership with Gateway For Cancer Research


13 Children's hospitals across the U.S. awarded to support pilot and early phase clinical trials enabling nearly 150 new patients to enroll.



Map of Hospitals/Institutions Receiving CCIA Grants



MORE INFORMATION

A FOCUS ON FAMILY


In addition to driving research to end children's cancer, CureSearch is committed to supporting families and communities facing cancer today.


On September 12, 2011, eighteen-month-old Anna Pitts was diagnosed with acute lymphoblastic leukemia (ALL). Anna's family has been involved in the CureSearch Walk for the past two years, and Mom, Krissy Pitts, serves on the CureSearch National Walk Committee.


Read Her Full Story
  The Pitts Family

Anna Pitts

Anna Pitts
Acute Lymphoblastic Leukemia (ALL)

EDUCATION


Our website, which attracts more than 500,000 visitors per year, offers a broad spectrum of educational resources and tools:




NEW FOR 2015

Our CureSearch CancerCare mobile app!


The mobile app launched in September as part of our Childhood Cancer Awareness Month activities.



Check out the dedicated webpage including video and screen shots.

 

Available on the App StoreGet it on Google Play

CURESEARCH PARTNERS


Our work would not be possible without the generous support of thousands of Walkers, Hikers, Challenge-Seekers, and donors.


It is our honor to recognize the following partners for their extraordinary support:


Genentech  |  Love Your Melon  |  eBay giving works
Shark Shootout Charities  |  Anonymous
Hallmark Keepsake Ornament Club

DONOR FUNDS AND ULTIMATE GIFTS


CureSearch is grateful to the families who have established a Champion or Legacy Fund to honor their child:


Jacob Koenigs 'Jakefest' Memorial Fund and Kiewit
Joey Keller Legacy Fund
Nick Currey Fund
Amy Miller Champion Fund

Luke McGuire Legacy Fund
Danielle's Roses Champion Fund
Hammond Family Fund
Eloise Dodge Gould Legacy Fund




The ultimate gift to support children with cancer is a bequest in your final estate plan. CureSearch is honored to be included in the final plans of these extraordinary people:


Jean B. Michael
Robert T. Ridley

HONOR YOUR CHILD WITH A LEGACY OR CHAMPION FUND


INCLUDE CURESEARCH IN YOUR WILL OR ESTATE PLAN

EVENTS


You want an end to children's cancer. We do too. Let's work together to raise awareness and the money it takes to find cures. Events are a great way to do both.


CureSearch offers events focused on:


WALKS HIKES
FITNESS CHALLENGES KIDS
CREATE YOUR OWN EVENT

BEING SOCIAL...ON SOCIAL MEDIA


We are shining the spotlight on children's cancer on various social media channels where we post new research developments, stories about members of our CureSearch family, videos, photos and more. Join the conversation:


  • Facebook
  • Twitter
  • LinkedIn
  • Pinterest
  • Instagram

Join the fight to end children's cancer.

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