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Hepatocellular carcinoma is seen more frequently in areas of the world that have high rates of hepatitis. Infection with any one of several viruses that cause hepatitis is believed to be responsible.
Only a few risk factors for hepatoblastoma are known for sure.
Genetic conditionsChildren with some genetic syndromes are more likely to develop hepatoblastoma than other children. These syndromes are Beckwith-Wiedemann syndrome and Familial Adenomatous Polyposis. Children with these genetic conditions are more at risk for hepatoblastoma, but these account for only a small fraction of cases. These syndromes usually require medical care, so you would know if your child had one of them.
Low birth weightBabies weighing less than 1,500 grams or about 3½ pounds at birth have a much higher risk of hepatoblastoma compared to normal weight babies. Babies that are smaller than average (3 pounds 5 ounces - 5 pounds 8 ounces) have a slightly increased risk of developing hepatoblastoma. The reasons for the high risk associated with lower birth weights are not clear. Most children who are born with low birth weight never develop hepatoblastoma.
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